Water → Ethyl alpha-phthalimidopentanoate

HRID 26313

Reaktionsgleichung

Reaktionsgleichung von HRID 26313
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].[CH2:13]([O:15][C:16](=[O:22])[CH:17](Br)[CH2:18][CH2:19][CH3:20])[CH3:14].C(Cl)(Cl)Cl.O>CN(C)C=O>[C:1]1(=[O:11])[N:5]([CH:17]([CH2:18][CH2:19][CH3:20])[C:16]([O:15][CH2:13][CH3:14])=[O:22])[C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12

Komponenten

6

Edukt 4

HCID 962WaterHCID 6212ChloroformHCID 79071Ethyl 2-bromovalerateHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 13791337Ethyl alpha-phthalimidopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

To a solution of potassium phthalimide (0.1 mole) in about 50 ml of dimethylformamide (DMF) is added 1 equivalent of ethyl-2-bromopentanoate. The temperature is maintained at about 60° C. for 10 minutes. Chloroform is added to the cooled DMF solution and the mixture is poured into water. The phases are separated and the aqueous phase is extracted with chloroform. The chloroform extracts are combined, extracted with 0.1 N sodium hydroxide and with water. After drying over sodium sulfate, the chloroform is removed to give ethyl α-phthalimidopentanoate.

Aufarbeitung

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with chloroform
  3. extractionextracted with 0.1 N sodium hydroxide and with water
  4. dry with materialAfter drying over sodium sulfate
  5. customthe chloroform is removed

Quellen und Nachweise

ORD-Eintrag
ord-238e2c7868bf4c0ab667f4ccfcc35579
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04148998

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