Water → 3-Oxo-2-(2,4,6-trimethyl-phenyl)-propionitrile

HRID 263700

Reaktionsgleichung

Reaktionsgleichung von HRID 263700
C[O-].[Na+].[CH:4](OCC)=[O:5].[CH3:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[C:11]=1[CH2:18][C:19]#[N:20].O>C1C=CC=CC=1>[CH:4]([CH:18]([C:11]1[C:12]([CH3:17])=[CH:13][C:14]([CH3:16])=[CH:15][C:10]=1[CH3:9])[C:19]#[N:20])=[O:5]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8025Ethyl formateHCID 5206982,4,6-TrimethylphenylacetonitrileHCID 10942334Sodium Methoxide

Produkt 1

HCID 224743973-Oxo-2-(2,4,6-trimethyl-phenyl)-propionitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a stirred mixture of sodium methoxide (2.78 g, 51 mmol) and ethyl formate (4.0 g, 54 mmol) in 100 mL of benzene was added 2,4,6 trimethylphenylacetonitrile (8.0 g, 50 mmol) over 5 min. After stirring for an additional hour it was treated with water (100 mL) and the layers were separated. The aqueous layer was separated and acidified with 10% HCl and extracted with ethyl acetate. After drying the solvent was removed in vacuo to afford a-formyl-2,4,6-trimethylphenylacetonitrile as colorless crystals melting at 120°-122° C.

Aufarbeitung

  1. customthe layers were separated
  2. customThe aqueous layer was separated
  3. extractionextracted with ethyl acetate
  4. customAfter drying the solvent
  5. customwas removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-51083602d49a4444b155fca3f57b2e95
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05644057

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