Hydrochloric Acid → 4-Methylbenzene-1-carboximidamide hydrochloride

HRID 264760

Reaktionsgleichung

Reaktionsgleichung von HRID 264760
[C:1]1([CH3:9])[CH:6]=[CH:5][C:4]([C:7]#[N:8])=[CH:3][CH:2]=1.C[Si]([N-:14][Si](C)(C)C)(C)C.[Li+].[ClH:20]>C(OCC)C>[ClH:20].[CH3:9][C:1]1[CH:6]=[CH:5][C:4]([C:7]([NH2:14])=[NH:8])=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 7724p-TolunitrileHCID 2733832Lithium Hexamethyldisilazide

Produkt 1

HCID 1227534-Methylbenzene-1-carboximidamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of 12.4 g p-tolunitrile in 500 mL of diethyl ether was added 23 g of solid lithium bis(trimethylsilyl)amide at ambient temperature. The mixture was stirred for 2 hours then hydrolysed with 10% HCl at 0° C. The mixture was stirred for an additional 30 minutes and then concentrated to dryness to yield 6 g of 4-methylbenzamidine hydrochloride which was used in the next step without further purification

Aufarbeitung

  1. stirringThe mixture was stirred for an additional 30 minutes
  2. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-04948d1ce4804c4f88f2d37ab60e9149
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646281

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