Hippuric Acid → Azlactone

Reaktionsgleichung

[C:1]([OH:13])(=[O:12])[CH2:2][NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.C(OC(=O)C)(=O)C>>[C:6]1([C:4]2[O:13][C:1](=[O:12])[CH2:2][N:3]=2)[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Komponenten

Edukt 2

HCID 464Hippuric Acid

HCID 7918Acetic Anhydride

Produkt 1

HCID 65073Azlactone

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

657 gm (3.66 mol) of hippuric acid and 2,618 gm of acetic anhydride were charged into a 5 1 glass reaction vessel, and heated at 80° C. for 15 minutes. When the reaction liquid became transparent, the reaction vessel was placed into a water bath to lower the internal temperature to 30° C., followed by cooling to 0° C. on a dry ice-methanol bath.

Aufarbeitung

customWhen the reaction liquid
customthe reaction vessel was placed into a water bath
customto 30° C.
temperatureby cooling to 0° C. on a dry ice-methanol bath

Quellen und Nachweise

ORD-Eintrag: ord-12ba796543474e9985980c22ae46cfd2
Quelldatensatz: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05646291

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