Hydrochloric Acid → HCID 178440151, Verbindung

HRID 265050Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 265050
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:7]=1[C:8]([O:10]CC)=[O:9].O.[OH-].[Li+].Cl>O>[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:18][CH:19]=2)[C:7]=1[C:8]([OH:10])=[O:9]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 178440150HCID 178440150, Verbindung

Produkt 1

HCID 178440151HCID 178440151, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 0.20 g of ethyl 4-hydroxymethyl -2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 35(c)] and 0.10 g of lithium hydroxide monohydrate in 3 ml of water was stirred at room temperature for 3 hours, after which it was allowed to stand for 16 hours at the same temperature. The reaction mixture was then mixed with 2.38 ml of 1N aqueous hydrochloric acid and the resulting precipitate was collected by filtration, to give 150 mg of the title compound, melting at 233° C. (with decomposition).

Aufarbeitung

  1. waitto stand for 16 hours at the same temperature
  2. filtrationthe resulting precipitate was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-9e7f6ecef7c34f8ca89cb9f5e85b2d23
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646171

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