1,2-Dichloroethane → 5-nitro-1H-indole-3-carbaldehyde

HRID 266705

Reaktionsgleichung

Reaktionsgleichung von HRID 266705
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=C2)([O-:3])=[O:2].[OH2:13].Cl[CH2:15][CH2:16]Cl>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH:8]=[C:15]2[CH:16]=[O:13])([O-:3])=[O:2]

Komponenten

4

Edukt 3

HCID 111,2-DichloroethaneHCID 962WaterHCID 225235-Nitroindole

Produkt 1

HCID 2460395-nitro-1H-indole-3-carbaldehydeAusbeute 80 %

Versuchsvorschrift

Then a solution of 5-nitroindole (1.62 g, 0.01 mol) in 1,2-dichloroethane (50 ml) was added and the mixture heated to reflux for 3 h. After cooling the mixture was poured onto iced water, the precipitate filtered off and washed with water. Thereupon the residue was chromatographed over silica gel using benzene/ethylacetate as eluant. Thus pure title compound was obtained in 80% yield (1.52 g).

Aufarbeitung

  1. temperaturethe mixture heated
  2. temperatureto reflux for 3 h
  3. temperatureAfter cooling the mixture
  4. filtrationthe precipitate filtered off
  5. washwashed with water
  6. customThereupon the residue was chromatographed over silica gel

Quellen und Nachweise

ORD-Eintrag
ord-437773589cd8425ca6c3f8964c69b5a6
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05652250

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