Ethyl isobutyrylacetate → HCID 178472908, Verbindung

HRID 26821

Reaktionsgleichung

Reaktionsgleichung von HRID 26821
[N:1]([O-:3])=O.[Na+].[C:5]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])(=[O:9])[CH:6]([CH3:8])[CH3:7]>O.C(O)(=O)C>[N:1](=[C:10]([C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[C:11]([O:13][CH2:14][CH3:15])=[O:12])[OH:3]

Komponenten

5

Edukt 2

HCID 81583Ethyl isobutyrylacetateHCID 23668193Sodium Nitrite

Produkt 1

HCID 178472908HCID 178472908, VerbindungAusbeute 94,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

A solution of sodium nitrite (43.8 g.) in water (92 ml.) was added dropwise, with stirring, to a solution of ethyl isobutyrylacetate (100.3 g.) in acetic acid (80 ml.) at 0°. After stirring at 0° for 30 minutes then at room temperature for 3 hours, water (100 ml.) was added and the mixture extracted with ether. The extracts were washed with water, saturated sodium bicarbonate solution and water. After drying (CaSO4), the solution was evaporated to give ethyl 2-oximino-4-methyl-3-oxopentanoate (112 g.) as a crude oil.

Aufarbeitung

  1. waitat room temperature for 3 hours
  2. extractionthe mixture extracted with ether
  3. washThe extracts were washed with water, saturated sodium bicarbonate solution and water
  4. dry with materialAfter drying (CaSO4)
  5. customthe solution was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-bad3ca5e608a484e9c01ae3860fbcf37
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151288

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