Hydrogen iodide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26902

Reaktionsgleichung

Reaktionsgleichung von HRID 26902
C([O:3][C:4](=[O:23])[CH2:5][C:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)(O)[CH3:7])C.FC1C=C(F)C=CC=1C1C=CC(C(C)=CC(O)=O)=CC=1.I.OS([O-])=O.[Na+]>C(O)(=O)C>[F:22][C:16]1[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=1[C:12]1[CH:13]=[CH:14][C:9]([CH:6]([CH3:7])[CH2:5][C:4]([OH:23])=[O:3])=[CH:10][CH:11]=1

Komponenten

6

Edukt 4

HCID 24841Hydrogen iodideHCID 23665763Sodium BisulfiteHCID 538342513-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl esterHCID 540100683-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

Produkt 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, or the corresponding free hydroxy acid or 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, is heated with 2 ml. of 67% hydriodic acid and 4 ml. of acetic acid at 150° for 1 hour and the mixture is poured onto ice and decolorized with NaHSO3 solution. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°, is obtained.

Aufarbeitung

  1. additionthe mixture is poured onto ice

Quellen und Nachweise

ORD-Eintrag
ord-33adb9ea9eaf4650a352ffb45849f2e3
Quelldatensatz
uspto-grants-1979_04
Patentnummer
US04151302

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