Triethylamine → HCID 69312113, Verbindung

HRID 269530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 269530
[C:1](Cl)(=[O:5])[CH2:2][CH2:3][CH3:4].[CH3:7][O:8][C:9]([C:11]1[CH:12]=[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Br:24])[CH:14]=[C:15]([NH2:17])[CH:16]=1)=[O:10].C(N(CC)CC)C>ClCCl.C(OCC)C>[CH3:7][O:8][C:9]([C:11]1[CH:12]=[C:13]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Br:24])[CH:14]=[C:15]([NH:17][C:1](=[O:5])[CH2:2][CH2:3][CH3:4])[CH:16]=1)=[O:10]

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 8855Butyryl chlorideHCID 693107195-Amino-2'-bromobiphenyl-3-carboxylic acid methyl ester

Produkt 1

HCID 69312113HCID 69312113, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 3283Diethyl EtherLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Butyryl chloride (55 mg, 0.52 mmol) was added to a solution of 5-amino-2′-bromo-biphenyl-3-carboxylic acid methyl ester (153 mg, 0.5 mmol) and triethylamine (76 mg, 0.75 mmol) in dichloromethane (5 ml) and the mixture left at room temperature for 30 minutes. The resulting solution was diluted with diethyl ether, washed with 1M hydrochloric acid and saturated sodium bicarbonate, dried (MgSO4) and evaporated to dryness to yield the title compound as a light yellow gum. (161 mg, 88%).

Aufarbeitung

  1. washwashed with 1M hydrochloric acid and saturated sodium bicarbonate
  2. dry with materialdried (MgSO4)
  3. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-70c6d69bcc764d978ccd31c8ab4f8bcd
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07446222B2

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