Diacetone Alcohol → 4-Hydroxy-4-methyl-pentan-2-one oxime
Reaktionsgleichung
[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=O)[CH3:5].Cl.[NH2:10][OH:11].C(=O)(O)[O-].[Na+]>O>[OH:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](=[N:10][OH:11])[CH3:5]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 4-hydroxy-4-methyl-2-pentanone (10.0 g, 85.7 mmole) and hydroxylamine hydrochloride (22.17 g, 343 mmole) in 90 ml of water was stirred vigorously at room temperature. To this solution was added slowly over a period of an hour solid sodium bicarbonate (26.8 g, 343 mmole). After 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml), dried (MgSO4) and evaporated under reduced pressure, to give the product as an oil. Yield 11.2 g
Aufarbeitung
- extractionAfter 3 hours the reaction mixture was extracted with ethyl acetate (3×, 100 ml)
- dry with materialdried (MgSO4)
- customevaporated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-5ea092ec175b430aaa850965a685d7f9
- Quelldatensatz
- uspto-grants-2008_11
- Patentnummer
- US07449581B2
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