Bromine → 5-Bromo-6-chloropyrimidine-2,4-diol

HRID 271422

Reaktionsgleichung

Reaktionsgleichung von HRID 271422
[Cl:1][C:2]1[NH:7][C:6](=[O:8])[NH:5][C:4](=[O:9])[CH:3]=1.[Br:10]Br>O>[Br:10][C:3]1[C:4](=[O:9])[NH:5][C:6](=[O:8])[NH:7][C:2]=1[Cl:1]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 732726-Chlorouracil

Produkt 1

HCID 5898345-Bromo-6-chloropyrimidine-2,4-diolAusbeute 61,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a stirring and refluxing solution of 6-chloropyrimidine-2,4(1H,3H)-dione (10.0 g, 68.25 mmol) in water (100 mL) was added bromine (4 mL, 79.84 mmol)) over 10 min. The colorless precipitate that formed was collected by filtration, washed with water (50 mL×2), and dried in a vacuum oven at 50° C. overnight, to obtain 9.4 g of the title compound as a white solid. HPLC/MS: retention time=1.05 min, [M+H]30 =225.

Aufarbeitung

  1. customThe colorless precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water (50 mL×2)
  4. customdried in a vacuum oven at 50° C. overnight

Quellen und Nachweise

ORD-Eintrag
ord-36f4b4f8f9444ba68960dafb5f4540de
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452892B2

Verknüpfte Notizen

Wird geladen…