Hydrochloric Acid → tert-Butyl 4-(pyridin-2-yl)piperidine-1-carboxylate

Temperatur

65 °C

Zinc powder (10.50 g, 160.60 mmol) was added to 2M hydrochloric acid (25 mL) and the resulting suspension was stirred for 20 minutes. It was then filtered and washed with water (10 mL), ethanol (10 mL), diethyl ether (10 mL) and dried in a vacuum oven for 24 hours. The dried zinc was suspended in N,N-dimethylformamide (50 mL) and 1,2-dibromoethane (277 μL, 3.21 mmol) was added. The resulting suspension was warmed to 65° C. for 5 minutes and then allowed to cool to room temperature, after which time trimethylsilyl chloride (406 μL, 3.2 mmol) was added. The reaction was stirred at room temperature for 45 minutes and then a solution of tert-butyl 4-iodopiperidine-1-carboxylate (Synlett, 4, 379, 1998) (10 g, 32.1 mmol) and hydroquinone (177 mg, 0.05 mmol) in N,N-dimethylformamide (50 mL) was slowly added, followed by warming to 150° C. for 30 minutes. 2-bromopyridine (3.06 mL, 32.10 mmol) in N,N-dimethylformamide (20 mL) was then added, followed by 5 mol % of Pd2(dba)3 (1.44 g, 1.57 mmol), 10 mol % P-(2-furyl)3 (747 mg, 3.22 mmol) and the reaction was heated at 65° C. for 24 hours. The reaction mixture was filtered through Celite® and diluted with water (500 mL). It was then extracted with diethyl ether (2×250 ml). The organic layers were combined and washed with brine, dried over magnesium sulfate and concentrated in vacuo to give the crude residue. Purification by column chromatography on silica gel using diethyl ether:pentane (50:50-100:0) as eluent afforded the product as a yellow oil, 1.9 g (23%).

1. filtrationIt was then filtered
2. washwashed with water (10 mL), ethanol (10 mL), diethyl ether (10 mL)
3. customdried in a vacuum oven for 24 hours
4. temperatureto cool to room temperature
5. stirringThe reaction was stirred at room temperature for 45 minutes
6. temperatureby warming to 150° C. for 30 minutes
7. temperaturethe reaction was heated at 65° C. for 24 hours
8. filtrationThe reaction mixture was filtered through Celite®
9. additiondiluted with water (500 mL)
10. extractionIt was then extracted with diethyl ether (2×250 ml)
11. washwashed with brine
12. dry with materialdried over magnesium sulfate
13. concentrationconcentrated in vacuo
14. customto give the crude residue
15. customPurification by column chromatography on silica gel

ORD-Eintrag

ord-3a04ff1ca1784d598b4fd6f3f1350e87

Quelldatensatz

uspto-grants-2008_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07456170B2