2,5-Dimethoxytetrahydrofuran → HCID 14962883, Verbindung

HRID 274603Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 274603
[NH2:1][C:2]1[N:3]=[C:4]([CH2:12][CH2:13][CH3:14])[NH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].C([O-])(=O)C.[Na+].CO[CH:22]1[CH2:26][CH2:25][CH:24](OC)O1>C(O)(=O)C>[CH2:12]([C:4]1[NH:5][C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[C:2]([N:1]2[CH:22]=[CH:26][CH:25]=[CH:24]2)[N:3]=1)[CH2:13][CH3:14]

Komponenten

5

Edukt 3

HCID 790982,5-DimethoxytetrahydrofuranHCID 517045Sodium AcetateHCID 20093493ethyl 4-amino-2-propyl-1H-imidazole-5-carboxylate

Produkt 1

HCID 14962883HCID 14962883, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

A solution of ethyl 4-amino-2-propylimidazole-5-carboxylate from above (9.34 g, 47 mmol) and sodium acetate (23.2 g) in acetic acid (100 mL) was heated to reflux and treated with 2,5-dimethoxy-tetrahydrofuran (6.75 mL, 52 mmol). The reaction was held at reflux for 30 minutes, then cooled back to room temperature with an ice bath. The majority of the acetic acid was evaporated under reduced pressure, then the residue was partitioned between ethyl acetate and 10% aqueous K2CO3 (120 mL) each. The organic layer was dried over MgSO4 and evaporated. The residue was purified by flash chromatography on silica gel, eluting with CH2Cl2 -ethyl acetate (80:20). Evaporation of solvents gave a solid which was recrystallized from hexane/EtOAc (1:1) to give 7.4 g of the title compound, mp 134°-135° C.; MS (CI), 248 (m +1).

Aufarbeitung

  1. temperatureto reflux
  2. temperatureat reflux for 30 minutes
  3. customThe majority of the acetic acid was evaporated under reduced pressure
  4. customthe residue was partitioned between ethyl acetate and 10% aqueous K2CO3 (120 mL) each
  5. dry with materialThe organic layer was dried over MgSO4
  6. customevaporated
  7. customThe residue was purified by flash chromatography on silica gel
  8. washeluting with CH2Cl2 -ethyl acetate (80:20)
  9. customEvaporation of solvents
  10. customgave a solid which
  11. customwas recrystallized from hexane/EtOAc (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-7479a98218bd464a9071c382448dad5c
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389661

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