2,5-Dimethylaniline → N-(2,5-Dimethylphenyl)acetamide

HRID 275994

Reaktionsgleichung

Reaktionsgleichung von HRID 275994
[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH2:4].[C:10](OC(=O)C)(=[O:12])[CH3:11]>CN(C)C1C=CN=CC=1.ClCCl>[CH3:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH:4][C:10](=[O:12])[CH3:11]

Komponenten

5

Edukt 2

HCID 72592,5-DimethylanilineHCID 7918Acetic Anhydride

Produkt 1

HCID 16304N-(2,5-Dimethylphenyl)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 2,5-dimethylaniline (5.30 g) and 4-dimethylaminopyridine (6.41 g) in dichloromethane (90 ml) was added acetic anhydride (4.13 ml) under ice-cooling, and the mixture was stirred for 4 hours. The reaction mixture was washed with 1N hydrochloric acid and a saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate. Removal of the solvent in vacuo gave 2′,5′-dimethylacetanilide (6.09 g).

Aufarbeitung

  1. temperaturecooling
  2. washThe reaction mixture was washed with 1N hydrochloric acid
  3. dry with materiala saturated aqueous sodium bicarbonate solution subsequently, and dried over anhydrous magnesium sulfate
  4. customRemoval of the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-e1d948e4bff14b87b806b0d181e33941
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353025B1

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