Benzaldehyde → Heptanophenone

HRID 276160

Reaktionsgleichung

Reaktionsgleichung von HRID 276160
[CH:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.NC1C(C)=CC=CN=1.C(O)(=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C=CCCCC.C1(C)C=CC=CC=1>>[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:8])[CH2:22][CH2:23][CH2:18][CH2:19][CH2:20][CH3:21]

Komponenten

6

Edukt 5

HCID 240BenzaldehydeHCID 243Benzoic AcidHCID 1140TolueneHCID 115971-HexeneHCID 153472-Amino-3-methylpyridine

Produkt 1

HCID 74282Heptanophenone

Reaktionsbedingungen

Temperatur
130 °C

Versuchsvorschrift

Under the same reaction procedure and conditions as in Example 1 (benzaldehyde 0.5 mmol, 2-amino-3-picoline 0.1 mmol, bezoic acid 0.03 mmol, 1-hexene 2.5 mmol, toluene 0.87 mmol), various kinds of amines 0.3 mmol as shown in the following table 5, were added to each 500 ml pressure reactor. The mixture was stirred at normal temperature for 2-3 minutes and then combined with Rh(PPh3)3Cl 0.01 mmol. While the reactor was stopped with a stopper, the reactants were heated at 130° C. for 1 hour with stirring. After completion of the reaction, column chromatography was conducted to determine the yields of heptanophenone, products according to various amines. The results are given in Table 5, below.

Aufarbeitung

  1. additionwere added to each 500 ml pressure reactor
  2. stirringwith stirring
  3. customAfter completion of the reaction, column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e5e44ed7f59d431392a6aa614d158671
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353139B1

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