Acetic Acid → (1S,2R)-(+)-Norephedrine

HRID 27843

Reaktionsgleichung

Reaktionsgleichung von HRID 27843
C(O)(=O)C.[N+:5]([CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10])([O-])=O>C(O)(C)C>[NH2:5][CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10]

Komponenten

4

Edukt 2

HCID 176Acetic AcidHCID 2261182-Nitro-1-phenyl-1-propanol

Produkt 1

HCID 4786(1S,2R)-(+)-Norephedrine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

In the practice of this invention, the 2-nitro-1-phenyl-1-propanol is dissolved in a lower alkyl alcohol, preferably isopropyl alcohol. The mixture is placed in a vessel suitable for high pressure reactions and equipped with agitation means, e.g. a rocking bomb or a stirred bomb. Acetic acid is added to the solution to produce the acetate salt of 2-amino-1-phenyl-1-propanol during the reduction reaction.

Aufarbeitung

  1. customThe mixture is placed in a vessel suitable for high pressure reactions
  2. customequipped with agitation means, e.g. a rocking bomb

Quellen und Nachweise

ORD-Eintrag
ord-4cded8dcbfd6476790085eff15e94b2e
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04224246

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