Acetic Acid → (1S,2R)-(+)-Norephedrine
Reaktionsgleichung
C(O)(=O)C.[N+:5]([CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10])([O-])=O>C(O)(C)C>[NH2:5][CH:8]([CH3:17])[CH:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In the practice of this invention, the 2-nitro-1-phenyl-1-propanol is dissolved in a lower alkyl alcohol, preferably isopropyl alcohol. The mixture is placed in a vessel suitable for high pressure reactions and equipped with agitation means, e.g. a rocking bomb or a stirred bomb. Acetic acid is added to the solution to produce the acetate salt of 2-amino-1-phenyl-1-propanol during the reduction reaction.
Aufarbeitung
- customThe mixture is placed in a vessel suitable for high pressure reactions
- customequipped with agitation means, e.g. a rocking bomb
Quellen und Nachweise
- ORD-Eintrag
- ord-4cded8dcbfd6476790085eff15e94b2e
- Quelldatensatz
- uspto-grants-1980_09
- Patentnummer
- US04224246
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