Hydrazine hydrate (1:1) → 3(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

HRID 27895

Reaktionsgleichung

Reaktionsgleichung von HRID 27895
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1.O.[NH2:16][NH2:17].O1CCOCC1>O>[NH:16]([C:2]1[N:3]=[N:4][C:5]([N:8]2[C:12]([CH3:13])=[CH:11][C:10]([CH3:14])=[N:9]2)=[CH:6][CH:7]=1)[NH2:17]

Komponenten

5

Edukt 3

HCID 24654Hydrazine hydrate (1:1)HCID 312751,4-DioxaneHCID 3210733-Chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine

Produkt 1

HCID 30539723(2H)-Pyridazinone, 6-(3,5-dimethyl-1H-pyrazol-1-yl)-, hydrazone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 34.2 g. of 3-chloro-6-(3,5-dimethyl-1-pyrazolyl)-pyridazine, 100 ml of 72% hydrazine hydrate and 200 ml of dioxane is stirred at 90°-95° C. for 14 hours, then the mixture is poured into 1 liter of water, extracted three times with 150 ml of chloroform each, and the combined organic phases are dried over magnesium sulphate. After evaporation of the solvent, the residue is recrystallized from isopropanol. Yield: 27 g /80%/; m.p.: 142°-143° C.

Aufarbeitung

  1. additionA mixture of 34.2 g
  2. extractionextracted three times with 150 ml of chloroform each, and the combined organic phases
  3. dry with materialare dried over magnesium sulphate
  4. customAfter evaporation of the solvent
  5. customthe residue is recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-4ac82b5535e94a9f90c855027f1f8454
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04224325

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