Chlorotrimethylsilane → 4-Methyl-2-trimethylsilylthiazole

HRID 2798

Reaktionsgleichung

Reaktionsgleichung von HRID 2798
C([Li])CCC.[CH3:6][C:7]1[N:8]=[CH:9][S:10][CH:11]=1.[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>C(OCC)C>[CH3:6][C:7]1[N:8]=[C:9]([Si:13]([CH3:15])([CH3:14])[CH3:12])[S:10][CH:11]=1

Komponenten

5

Edukt 3

HCID 6397ChlorotrimethylsilaneHCID 127484-MethylthiazoleHCID 178418339Butyllithium

Produkt 1

HCID 116583544-Methyl-2-trimethylsilylthiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.

Aufarbeitung

  1. customwas then quenched by the addition of saturated aqueous sodium hydrogen carbonate
  2. distillationWork-up in the normal fashion and vacuum distillation

Quellen und Nachweise

ORD-Eintrag
ord-5a7b382c7d5a4739a7806a3eb2f4a308
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731335

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