2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → HCID 13654083, Verbindung

HRID 280450Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 280450
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[NH:10][NH2:11].[CH2:14]([O:16][C:17](=[O:25])[C:18](=[CH:21]OCC)[C:19]#[N:20])[CH3:15]>C(O)(=O)C.O>[NH2:20][C:19]1[N:10]([C:4]2[CH:5]=[CH:6][C:7]([Cl:9])=[CH:8][C:3]=2[C:2]([F:1])([F:12])[F:13])[N:11]=[CH:21][C:18]=1[C:17]([O:16][CH2:14][CH3:15])=[O:25]

Komponenten

5

Edukt 2

HCID 789432-Propenoic acid, 2-cyano-3-ethoxy-, ethyl esterHCID 2778240(4-Chloro-2-(trifluoromethyl)phenyl)hydrazine

Produkt 1

HCID 13654083HCID 13654083, VerbindungAusbeute 85,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 176Acetic AcidLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of 31.58 g of 2-(trifluoromethyl)-4-chlorophenylhydrazine and 27.92 g of ethyl(ethoxymethylene)cyanoacetate dissolved in 225 of acetic acid and 75 ml of water was heated on a steam bath for approximately 16 hours. The reaction mixture was cooled to room temperature and placed in the refrigerator. The precipitated solid was collected by filtration and combined with the solids isolated from the filtrate to provide 43 g of 5-amino-1-[2-(trifluoromethyl)-4-chlorophenyl]-1H-pyrazole-4-carboxylic acid, ethyl ester. MP=114°-116° C.

Aufarbeitung

  1. temperaturewas heated on a steam bath for approximately 16 hours
  2. filtrationThe precipitated solid was collected by filtration
  3. customisolated from the filtrate

Quellen und Nachweise

ORD-Eintrag
ord-9726254e7b62442ab15a5e8aa42de1e7
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04589905

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