Hydrochloric Acid → Methyl 4-amino-2-methanesulfonyloxybenzoate hydrochloride

HRID 280834Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 280834
[CH3:1][S:2]([O:5][C:6]1[CH:15]=[C:14]([N+:16]([O-])=O)[CH:13]=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9])(=[O:4])=[O:3].[ClH:19]>[Pd].C(O)(=O)C>[ClH:19].[NH2:16][C:14]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([O:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:15]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 23320160Methyl 2-[(methanesulfonyl)oxy]-4-nitrobenzoate

Produkt 1

HCID 23320164Methyl 4-amino-2-methanesulfonyloxybenzoate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Methyl 2-methanesulfonyloxy-4-nitrobenzoate (14 g) and palladium on carbon (0.5 g, 10%) were suspended in 400 ml of acetic acid and hydrochloric acid (5 ml, density 1.18). The suspension was hydrogenated in a Parr hydrogenation apparatus at 250 kPa. The palladium carbon was filtered off, and the solution was evaporated; the crystal mass was washed with ethyl acetate and dried. Yield: 11 g.

Aufarbeitung

  1. filtrationThe palladium carbon was filtered off
  2. customthe solution was evaporated
  3. washthe crystal mass was washed with ethyl acetate
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-547ee29b8cc149aa9dffe94f3681d771
Quelldatensatz
uspto-grants-1986_05
Patentnummer
US04591584

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