Hydrochloric Acid → 1-Amino-3-(tetrahydro-2H-pyran-2-yloxy)octane

Temperatur

0 °C

A 1.9 M solution (21 ml. 40 millimole) of n-butyl lithium in hexane is added cautiously to a stirred solution of freshly distilled diisopropylamine (4.04 g., 40 millimole) in anhydrous tetrahydrofuran (60 ml.) maintained at 0° C. under a nitrogen atmosphere. The resulting solution is stirred at ambient temperature for 15 minutes, cooled to -78° C., and treated with a solution of anhydrous acetonitrile (1.64 g., 40 millimole) in anhydrous tetrahydrofuran (5 ml.). The resulting turbid suspension is stirred and maintained at -78° C. for 30 minutes and then treated with a solution of hexanal (4.0 g., 40 millimole) in anhydrous tetrahydrofuran (5 ml.). After attaining a clear, yellow reaction solution, cooling at -78° C. is maintained for an additional 15 minutes. The cold reaction solution is treated with 2 N hydrochloric acid (50 ml.) and extracted with ether (100 ml.). The organic extract is washed with water (50 ml.) and 5% aqueous sodium bicarbonate (50 ml.), dried over magnesium sulfate, filtered and evaporated in vacuo, leaving the title compound as a pale yellow oil (5.2 g., 92%), pmr (CDCl3) δ0.97 (3H, t), 2.55 (2H, d), 3.10 (H, s) and 3.93 (H, bs).

1. temperaturecooled to -78° C.
2. stirringThe resulting turbid suspension is stirred
3. temperaturemaintained at -78° C. for 30 minutes
4. temperaturecooling at -78° C.
5. temperatureis maintained for an additional 15 minutes
6. extractionextracted with ether (100 ml.)
7. extractionThe organic extract
8. washis washed with water (50 ml.) and 5% aqueous sodium bicarbonate (50 ml.)
9. dry with materialdried over magnesium sulfate
10. filtrationfiltered
11. customevaporated in vacuo

ORD-Eintrag

ord-1777538a1384494dbf9a8d8b4ba4edbd

Quelldatensatz

uspto-grants-1980_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US04225609