Diethyl Ether → 2-(6-Chlorohexyloxy)tetrahydro-2H-pyran

To a mixture of 15 g of 6-chlorohexanol, 100 ml of methylenechloride and 0.2 g of p-toluenesulphonic acid were added dropwise 12 g of dihydropyrane in 40 ml of methylenechloride. The reaction mixture was stirred for 15 h at room temperature and then distributed between ether and saturated sodium bicarbonate solution. The ether phase was washed with water, dried over sodium sulphate, filtered and concentrated to dryness. Chromatography of the residue on silica using hexane/ether (3:1) gave 21 g of the product as a colourless oil.

1. washThe ether phase was washed with water
2. dry with materialdried over sodium sulphate
3. filtrationfiltered
4. concentrationconcentrated to dryness

ORD-Eintrag

ord-a770b83f1db64c9a9292a5aa6bd5ee65

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07419620B2