Sodium Chloride → N-[1-(4-aminophenyl)ethylidene]hydroxylamine

HRID 28616

Reaktionsgleichung

Reaktionsgleichung von HRID 28616
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH3:9])=[CH:4][CH:3]=1.Cl.[NH2:12][OH:13].[OH-].[Na+].[Cl-].[Na+]>C(O)C.O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:12][OH:13])[CH3:9])=[CH:4][CH:3]=1

Komponenten

7

Edukt 4

HCID 5234Sodium ChlorideHCID 7468p-AminoacetophenoneHCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 254131N-[1-(4-aminophenyl)ethylidene]hydroxylamineAusbeute 30 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a mixture of 1-(4-amino-phenyl)-ethanone (2.75 g, 20.3 mmol) and hydroxylamine hydrochloride salt (2.1 g, 30.5 mmol) in ethanol (200 ml) was added sodium hydroxide (4.1 g, 101.7 mmol) in water (50 ml). After stirring for 18 hours, the mixture was treated with saturated aqueous sodium chloride solution (100 ml) and extracted with dichloromethane (200 ml). The organic extract was concentrated under reduced pressure to afford 1-(4-amino-phenyl)-ethanone-oxime (30% yield).

Aufarbeitung

  1. extractionextracted with dichloromethane (200 ml)
  2. extractionThe organic extract
  3. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4d7aca234a664cbe99991eb96404e5e8
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07419984B2

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