Ethanol → N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

HRID 29732Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 29732
[Cl-:1].[NH4+].O.C(O)C.[N+:7]([C:10]1[CH:34]=[CH:33][C:13]([NH:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][NH:23][C:24]3[CH:29]=[CH:28][C:27]([N+:30]([O-])=O)=[CH:26][CH:25]=3)=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)([O-])=O>CN1C(=O)CCC1.[Zn]>[ClH:1].[ClH:1].[ClH:1].[ClH:1].[NH2:30][C:27]1[CH:26]=[CH:25][C:24]([NH:23][CH2:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][NH:14][C:13]3[CH:33]=[CH:34][C:10]([NH2:7])=[CH:11][CH:12]=3)=[CH:17][CH:18]=2)=[CH:29][CH:28]=1

Komponenten

7

Edukt 4

HCID 702EthanolHCID 962WaterHCID 25517Ammonium ChlorideHCID 236567624-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline

Produkt 1

HCID 69252903N-(4-{[(4-aminophenyl)amino]methyl}benzyl)benzene-1,4-diamine tetrahydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23994ZincKatalysatorHCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

The mixture of powdered zinc (22.2 g), ammonium chloride (2.5 g), water (4 ml) and absolute ethanol (20 ml) were brought to reflux with the oil bath. The 4-nitro-N-(4-{[(4-nitrophenyl)amino]methyl}benzyl)aniline (3.4 g) was dissolved in 20 ml of NMP and introduced dropwise until there was decoloration of the reaction medium, while at the same time the reflux was maintained.

Aufarbeitung

  1. temperatureto reflux with the oil bath
  2. additionintroduced dropwise until there
  3. temperaturewhile at the same time the reflux was maintained

Quellen und Nachweise

ORD-Eintrag
ord-210702c204ef409592efd42d6c840278
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07422609B2

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