2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-pyridin-3-ylbenzoic acid

HRID 30034

Reaktionsgleichung

Reaktionsgleichung von HRID 30034
Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.CON(C)C(=O)[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:22]2[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=2)=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 3

HCID 899062-Bromo-5-methoxybenzoic acidHCID 10558996N-Methoxy-N-methylnicotinamideHCID 178418339Butyllithium

Produkt 1

HCID 463159375-Methoxy-2-pyridin-3-ylbenzoic acid

Versuchsvorschrift

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-N-methylnicotinamide. After precipitation in aqueous phase at pH 4, followed by filtration and drying, a beige-coloured powder is obtained.

Aufarbeitung

  1. customThis compound is synthesized
  2. customAfter precipitation in aqueous phase at pH 4
  3. filtrationfollowed by filtration
  4. customdrying
  5. customa beige-coloured powder is obtained

Quellen und Nachweise

ORD-Eintrag
ord-3ea30621b6904a65840e6a85fe72c5cc
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423030B2

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