Water → 4-Benzylmorpholine-2-carbonitrile

HRID 30312

Reaktionsgleichung

Reaktionsgleichung von HRID 30312
[CH2:1]([NH:8][CH2:9][CH2:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC(=C)[C:14]#[N:15].O.[CH3:18][C:19](C)([O-])C.[K+]>O1CCCC1>[CH2:1]([N:8]1[CH2:19][CH2:18][O:11][CH:10]([C:14]#[N:15])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 4348BenzylethanolamineHCID 701982-ChloroacrylonitrileHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 156511954-Benzylmorpholine-2-carbonitrileAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Reaktionsbedingungen

Temperatur
-5 °C

Versuchsvorschrift

A one-litre reactor with mechanical stirring, cooled by an ice bath, is charged with N-benzylethanolamine (172.2 g; 1 equiv. available from Aldrich Chemical Company). 2-Chloroacrylonitrile (100 g; 1 equiv. available from Aldrich Chemical Company) is added dropwise over 2 minutes. The temperature is maintained between 23° C. and 29° C. by means of the ice bath and subsequently a water bath at 15° C. After one night stirring at room temperature (water bath), the mixture is dissolved in tetrahydrofuran and transferred to a 2 L reactor which is cooled to −5° C. by ice/NaCl bath. The total volume of tetrahydrofuran is 1.35 L. Potassium tert-butoxide (148 g; 1.1 equiv.) is added by portions over 1 hour, keeping the reaction temperature at 0±2° C. After 1 hour post-stirring at 0° C., the mixture is quenched with saturated NaHCO3 (500 mL). The aqueous layer is extracted with diethyl ether (500 mL). Organic layers are dried over MgSO4 and evaporated to dryness. The title compound (149.8 g; 65%) is obtained after percolation of the 250 g dry residue on 1 kg of SiO2, eluting with the following gradient:

Aufarbeitung

  1. temperatureA one-litre reactor with mechanical stirring, cooled by an ice bath
  2. customtransferred to a 2 L reactor
  3. customat 0±2° C
  4. customthe mixture is quenched with saturated NaHCO3 (500 mL)
  5. extractionThe aqueous layer is extracted with diethyl ether (500 mL)
  6. dry with materialOrganic layers are dried over MgSO4
  7. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-c84140ab63eb4002961380b2b4c12704
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423037B2

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