Ethanol → Ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate

HRID 30418

Reaktionsgleichung

Reaktionsgleichung von HRID 30418
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[SH:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].C(=O)([O-])[O-].[Na+].[Na+].CCO>O>[NH2:9][C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][CH:6]=2)[S:10][C:11]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 12185Ethyl ThioglycolateHCID 810792-Chloronicotinonitrile

Produkt 1

HCID 738459Ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylateAusbeute 93,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 2-chloro-3-cyanopyridine (330 g), ethyl 2-mercaptoacetate (361.2 g), sodium carbonate (265 g) and EtOH (1.2L) was heated to reflux for 4.5 hours. It was then cooled to ambient temperature, added to water (10 L) and the addition was washed in with water (5 L). The resulting slurry was stirred for 30 minutes and then it was filtered. The filter cake was washed with two portions of water (2×2.5 L) and dried at the pump. The solids were then dried to constant weight under vacuum at 45° C. to yield the title compound as a brown solid (493.1 g, 93.2%). δH (CDCl3) 8.68 (1H, dd, J 4.7, 1.2 Hz), 7.93 (1H, dd, J 8.5, 1.2 Hz), 7.29 (1H, dd, J 8.5, 4.7 Hz), 5.90 (2H, b), 4.38 (2H, q, J 7.0 Hz), 1.40 (3H, t, J 7.0 Hz). LCMS RT 2.9 minutes, 223 (M+H)+

Aufarbeitung

  1. temperaturewas heated
  2. temperatureto reflux for 4.5 hours
  3. additionthe addition
  4. washwas washed in with water (5 L)
  5. filtrationit was filtered
  6. washThe filter cake was washed with two portions of water (2×2.5 L)
  7. customdried at the pump
  8. customThe solids were then dried to constant weight under vacuum at 45° C.

Quellen und Nachweise

ORD-Eintrag
ord-958b7b90ea0c45cf995308ff1817ed7e
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423047B2

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