Water → 8-Amino-1,2,3,4-tetrahydronaphthalen-2-ol

HRID 30532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 30532
[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][C:9](=[O:12])[CH2:8][CH2:7]2.[BH4-].[Na+].O>CO>[NH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[CH2:10][CH:9]([OH:12])[CH2:8][CH2:7]2

Komponenten

5

Edukt 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 230669938-Amino-3,4-dihydro-1H-naphthalen-2-one

Produkt 1

HCID 230669958-Amino-1,2,3,4-tetrahydronaphthalen-2-olAusbeute 71,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Next, to 8-amino-3,4-dihydro-1H-naphthalen-2-one (0.050 g, 0.318 mmol) in methanol (10 mL) was added sodium borohydride (0.030 g, 0.175 mmol) at 0° C., and the mixture was stirred for 1 hour. The mixture was poured into water, and the product was extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure to afford 8-amino-1,2,3,4-tetrahydro-naphthalen-2-ol (0.037 g, 71% yield).

Aufarbeitung

  1. extractionthe product was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-65b5d5bf9c774a959f4dcd7e12449f55
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07423175B2

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