Dimethylformamide → 2-Oxobutyl benzoate

HRID 31659

Reaktionsgleichung

Reaktionsgleichung von HRID 31659
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[C:7]([O-:15])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Na+].CN(C)C=O>C(OCC)C>[C:7]([O:15][CH2:2][C:3](=[O:6])[CH2:4][CH3:5])(=[O:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 131561-Bromo-2-butanoneHCID 517055Sodium Benzoate

Produkt 1

HCID 157432722-Oxobutyl benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 1-bromobutan-2-one (7.2 g, 47.7 mmol), sodium benzoate (7.56 g, 52.4 mmol), and N,N-dimethylformamide (72 ml) was stirred at room temperature for 3 hours and 45 minutes. Diethyl ether was added to the reaction mixture and the mixture was washed with water and a saturated saline solution, dried over magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to obtain the title compound (9.5 g, quantitatively) as a light brown oil.

Aufarbeitung

  1. washthe mixture was washed with water
  2. dry with materiala saturated saline solution, dried over magnesium sulfate
  3. filtrationfiltrated
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7d7c0015b0cc406bb4bdac4994bc8c15
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07425634B2

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