Toluene → 2-Benzyloxy-6-bromopyridine

HRID 322063

Reaktionsgleichung

Reaktionsgleichung von HRID 322063
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[OH-:9].[K+].[C:11]1([CH3:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1OCCOCCOCCOCCOCCOC1>[CH2:17]([O:9][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 122742,6-DibromopyridineHCID 14797Potassium Hydroxide

Produkt 1

HCID 8174752-Benzyloxy-6-bromopyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2855718-Crown-6Katalysator

Versuchsvorschrift

A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.

Aufarbeitung

  1. temperatureunder reflux for 30 minutes
  2. washThe cool solution washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. customto give an oil which
  6. distillationis vacuum-distilled (Kugelrohr)

Quellen und Nachweise

ORD-Eintrag
ord-93682894d27b42bb9ad767ec95113533
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211220B1

Verknüpfte Notizen

Wird geladen…