Diethyl Ether → 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-acetoxymethylphenyl)benzamide

HRID 323147

Reaktionsgleichung

Reaktionsgleichung von HRID 323147
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:34]=[CH:33][C:20]([C:21]([N:23]([CH3:32])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[CH2:30][OH:31])=[O:22])=[CH:19][CH:18]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[C:35](OC(=O)C)(=[O:37])[CH3:36].C(OCC)C>N1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([C:14]([NH:16][C:17]3[CH:18]=[CH:19][C:20]([C:21]([N:23]([CH3:32])[C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[CH2:30][O:31][C:35](=[O:37])[CH3:36])=[O:22])=[CH:33][CH:34]=3)=[O:15])=[CH:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 220107654-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide

Produkt 1

HCID 220108024-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-acetoxymethylphenyl)benzamideAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A mixture of 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-hydroxymethylphenyl)benzamide (100 mg) and acetic anhydride (34 mg) in pyridine (5 ml) was stirred at ambient temperature for 3 days and the solvent was evaporated in vacuo. The residue was dissolved in chloroform and the organic solution was washed successively with 1N hydrochloric acid, water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give an oil and the oil was solidified with diethyl ether to give 4-(4′-methylbiphenyl-2-carboxamido)-N-methyl-N-(2-acetoxymethylphenyl)benzamide (105 mg) as a white powder.

Aufarbeitung

  1. customthe solvent was evaporated in vacuo
  2. dissolutionThe residue was dissolved in chloroform
  3. washthe organic solution was washed successively with 1N hydrochloric acid, water and brine
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent was evaporated in vacuo
  6. customto give an oil

Quellen und Nachweise

ORD-Eintrag
ord-5e765956fe104b108614d51939fadf75
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06211242B1

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