Hydrochloric Acid → (+/-)-5-[[5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid

HRID 324395Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 324395
[CH2:1]([C:3]1[O:4][C:5]2[CH:12]=[CH:11][C:10]3[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:9]=3[CH:8]([C:18]3[C:19](=[O:36])[NH:20][C:21](=[O:35])[N:22]([CH2:24][C:25]4[O:29][C:28]([C:30]([O:32]CC)=[O:31])=[CH:27][CH:26]=4)[CH:23]=3)[C:6]=2[N:7]=1)[CH3:2].O.[OH-].[Li+].Cl>CO.O>[CH2:1]([C:3]1[O:4][C:5]2[CH:12]=[CH:11][C:10]3[CH:13]=[C:14]([CH3:17])[CH:15]=[CH:16][C:9]=3[CH:8]([C:18]3[C:19](=[O:36])[NH:20][C:21](=[O:35])[N:22]([CH2:24][C:25]4[O:29][C:28]([C:30]([OH:32])=[O:31])=[CH:27][CH:26]=4)[CH:23]=3)[C:6]=2[N:7]=1)[CH3:2]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 131722500(+/-)-5-[[5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

Produkt 1

HCID 9804236(+/-)-5-[[5-(2-Ethyl-7-methyl-4H-benzo[5,6]cyclohepta[1,2-d]oxazol-4-yl)-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of the product of step (viii) (0.26 g) and lithium hydroxide monohydrate (0.063 g) in methanol (4 ml) and water (4 ml) was stirred at room temperature for 1.5 hours. The solution was neutralised by the addition of 2M hydrochloric acid and the solvents were evaporated under reduced pressure. Purification was by preparative HPLC followed by lyophilisation.

Aufarbeitung

  1. customthe solvents were evaporated under reduced pressure
  2. customPurification

Quellen und Nachweise

ORD-Eintrag
ord-47183b5df1f4426da8ee80d17122a7c0
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218376B1

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