Hydrochloric Acid → 2-Amino-5-(4-methoxyphenyl)-3-furancarbonitrile

HRID 32467Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 32467
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([C:7]([CH2:9][CH:10]([C:13]#[N:14])[C:11]#[N:12])=[O:8])=[CH:5][CH:4]=1.Cl.O>C(O)(=O)C>[NH2:12][C:11]1[O:8][C:7]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:16][CH:15]=2)=[CH:9][C:10]=1[C:13]#[N:14]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 153661992-(2-Oxo-2-(4-methoxyphenyl)ethyl)malononitrile

Produkt 1

HCID 241067882-Amino-5-(4-methoxyphenyl)-3-furancarbonitrileAusbeute 57,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a suspension of α-((4-methoxybenzoyl)methyl)malononitrile (9.66 g, 45.1 mmol) in acetic acid (50 ml) was added conc. hydrogen chloride (11,3 ml). The mixture was stirred at room temperature for 2 hours, and then poured into water. The resultant precipitation was filtrated, washed with water and ethanol, and dried under reduced pressure to give the Intermediate of Example 2(A) (5.54 g, 56%) as a solid. 1H NMR (400 MHz, CDCl3) ppm 3.83 (s, 3H), 4.74 (brs, 2H), 6.39 (s, 1H), 6.90 (m, 2H), 7.42 (m, 2H).

Aufarbeitung

  1. customThe resultant precipitation
  2. filtrationwas filtrated
  3. washwashed with water and ethanol
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-1996a01b8fb44706a2574631960b343b
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427623B2

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