3-Thiophen-2-ylprop-2-enoic acid → 3-(2-Thienyl)propanoic acid

HRID 324773

Reaktionsgleichung

Reaktionsgleichung von HRID 324773
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=[O:9]>C(O)C.[Pd]>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Komponenten

4

Edukt 1

HCID 928683-Thiophen-2-ylprop-2-enoic acid

Produkt 1

HCID 7031693-(2-Thienyl)propanoic acidAusbeute 77,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 3-(2-thienyl)acrylic acid (7 g) in ethanol was added 5% palladium on carbon and the mixture was hydrogenated at 50 psi in a Parr apparatus. The catalyst was filtered off and the solvent was removed by evaporation to yield the title compound (5.5 g) as an oil. Electrospray MS m/z 155 [M−H]+.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-1d78723a0ed54ea097bab6291d5bbe04
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06218538B1

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