Tetrahydrofuran → [6-(N-isopropylcarbamoyl)-2[4-(N-isopropylcarbamoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

HRID 325162

Reaktionsgleichung

Reaktionsgleichung von HRID 325162
Cl.O[C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH2:21][N:22]4[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]4)=[CH:15][CH:14]=3)=[O:12])=[C:9]([C:28]3[CH:33]=[CH:32][C:31](O)=[CH:30][CH:29]=3)[S:8][C:7]=2[CH:35]=1.C(N(CC)CC)C.[CH:43]([N:46]=[C:47]=[O:48])([CH3:45])[CH3:44].[N-:49]=[C:50]=[O:51].O1C[CH2:55][CH2:54][CH2:53]1>>[CH:43]([NH:46][C:47]([C:3]1[CH:4]=[CH:5][C:6]2[C:10]([C:11]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH2:20][CH2:21][N:22]4[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]4)=[CH:17][CH:18]=3)=[O:12])=[C:9]([C:28]3[CH:29]=[CH:30][C:31]([C:50](=[O:51])[NH:49][CH:54]([CH3:55])[CH3:53])=[CH:32][CH:33]=3)[S:8][C:7]=2[CH:35]=1)=[O:48])([CH3:45])[CH3:44]

Komponenten

6

Edukt 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 54900Raloxifene HydrochlorideHCID 61277Isopropyl isocyanateHCID 105034Isocyanate

Produkt 1

HCID 22001237[6-(N-isopropylcarbamoyl)-2[4-(N-isopropylcarbamoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone

Versuchsvorschrift

4 g (7.85 mmol) of [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride was suspended in 250 ml of anhydrous tetrahydrofuran and 3 g (30 mmol) of triethylamine was added. The reaction mixture was stirred for 15 minutes at room temperature and under nitrogen. 2.77 g (32.6 mmol) of isopropylisocyanate was added. After 24 hours, the reaction was checked by thin layer chromatography for completeness and was not complete. An additional 10.8 g (130.4 mmol) of the isocyanate was added and the reaction was allow to continue for another 96 hours. The desired compound was isolated substantially according to the procedures described in Example 19 to afford 4.01 g of the title compound as a tan amorphous powder.

Aufarbeitung

  1. waitAfter 24 hours
  2. waitto continue for another 96 hours

Quellen und Nachweise

ORD-Eintrag
ord-fab393552832498bb275b782c941d389
Quelldatensatz
uspto-grants-2001_04
Patentnummer
US06221838B1

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