Water → N-(Phenylmethoxy)guanidine

HRID 325526

Reaktionsgleichung

Reaktionsgleichung von HRID 325526
S([O-])([O-])(=O)=O.CS[C:8]([NH2:10])=[NH2+:9].CSC(N)=[NH2+].O.[CH2:17]([O:24][NH2:25])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[CH2:17]([O:24][NH:25][C:8]([NH2:10])=[NH:9])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 102313O-BenzylhydroxylamineHCID 6604939S-methyl isothiourea hemisulfate

Produkt 1

HCID 178513190N-(Phenylmethoxy)guanidine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 30.0 g. (0.12 moles) of S-methylthiouronium sulfate in 200 ml. of H2O there is added a solution of 24.6 g. (0.20 moles) of benzyloxyamine in 250 ml. of 95% ethanol. The mixture is stirred for 72 hours at room temperature. The clear solution is heated at reflux for two hours under a stream of nitrogen. The solvents are removed in vacuo and the residue is treated with 300 ml. of isopropanol. The solid is removed by filtration and dissolved in 300 ml. of water. The solution is made basic with 90 ml. of 10% aqueous sodium hydroxide. The precipitate is collected, washed with water and dried to give benzyloxyguanidine, m.p. 104°-5° C.

Aufarbeitung

  1. temperatureThe clear solution is heated
  2. temperatureat reflux for two hours under a stream of nitrogen
  3. customThe solvents are removed in vacuo
  4. additionthe residue is treated with 300 ml
  5. customThe solid is removed by filtration
  6. dissolutiondissolved in 300 ml
  7. customThe precipitate is collected
  8. washwashed with water
  9. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c8912a78a2f94778817ca45748f9f208
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04440949

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