Potassium Carbonate → 2-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]-N'-hydroxyethanimidamide

HRID 325978Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 325978
Cl[C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10][CH2:11][C:12]#[N:13])=[N:7][C:6]=2[CH:14]=1.[ClH:15].[OH:16][NH2:17].C(=O)([O-])[O-].[K+].[K+]>C(O)C.O>[Cl:15][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([S:10][CH2:11][C:12](=[NH:13])[NH:17][OH:16])=[N:7][C:6]=2[CH:14]=1

Komponenten

6

Edukt 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 13312471[(5-Chloro-1,3-benzothiazol-2-yl)sulfanyl]acetonitrile

Produkt 1

HCID 1785114642-[(5-chloro-1,3-benzothiazol-2-yl)sulfanyl]-N'-hydroxyethanimidamideAusbeute 34 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

14.4 g (0.6 m) (5-chloro-2-benzothiazolylthio)acetonitrile, prepared according to Example 1, 4.17 g (0.06 m) hydroxyamine hydrochloride and 4.14 g (0.03 m) potassium carbonate are dissolved in a mixture of 180 ml ethanol and 2 ml water. The mixture is heated overnight and then cooled. The solid which is collected is washed with water. The crude material is recrystallized from ethanol. The recrystallized product weighs 5.6 g (34% yield) and melts at 155°-7° C.

Aufarbeitung

  1. temperatureThe mixture is heated overnight
  2. temperaturecooled
  3. customThe solid which is collected
  4. washis washed with water
  5. customThe crude material is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-926b4f0ee0774c539a63db62e586c3ed
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04443606

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