5-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine → Pirmagrel

HRID 326129

Reaktionsgleichung

Reaktionsgleichung von HRID 326129
[C:1]([CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]>CO.[Pd]>[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:14]2[CH:15]=[N:16][CH:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)([OH:3])=[O:2]

Komponenten

4

Edukt 1

HCID 538080535-(5-Carboxypent-4-enyl)-imidazo[1,5-a]pyridine

Produkt 1

HCID 55390Pirmagrel

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 150 mg of 5-(5-carboxypent-4-enyl)-imidazo[1,5-a]pyridine in 7 ml methanol is added 100 mg of 10% palladium on carbon as catalyst. The reaction mixture is hydrogenated at atmospheric pressure for 3 hours. The catalyst is removed by filtration and the solvent evaporated under reduced pressure to yield 5-(5-carboxypentyl)-imidazo[1,5-a]pyridine melting at 144°-7°, and identical to the product of Example 2.

Aufarbeitung

  1. customThe catalyst is removed by filtration
  2. customthe solvent evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-4e20b28dbeee41708cc00e3314c66d4b
Quelldatensatz
uspto-grants-1984_04
Patentnummer
US04444775

Verknüpfte Notizen

Wird geladen…