Water → 1-Dimethylsulfamoyl-2-ethylimidazole

HRID 326469

Reaktionsgleichung

Reaktionsgleichung von HRID 326469
[CH2:1]([C:3]1[NH:4][CH:5]=[CH:6][N:7]=1)[CH3:2].C(N(CC)CC)C.[CH3:15][N:16]([CH3:21])[S:17](Cl)(=[O:19])=[O:18].O>C(Cl)(Cl)Cl>[CH3:15][N:16]([CH3:21])[S:17]([N:4]1[CH:5]=[CH:6][N:7]=[C:3]1[CH2:1][CH3:2])(=[O:19])=[O:18]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 661302-EthylimidazoleHCID 83372Dimethylsulphamoyl chloride

Produkt 1

HCID 232931831-Dimethylsulfamoyl-2-ethylimidazoleAusbeute 86,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added thereto and the organic layer is separated therefrom and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water. The solution is dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as colorless liquid.

Aufarbeitung

  1. customthe organic layer is separated
  2. concentrationconcentrated
  3. dissolutionThe residue is dissolved in ethyl acetate (1 liter)
  4. washwashed with water
  5. dry with materialThe solution is dried over sodium sulfate
  6. concentrationconcentrated
  7. distillationDistillation

Quellen und Nachweise

ORD-Eintrag
ord-a39ea9eac1b64affa0731f5f0d09ece4
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05268377

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