1-Dodecanol → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

HRID 327272

Reaktionsgleichung

[CH2:1]1[O:8]C(=O)C[O:4][C:2]1=[O:3].[CH3:9][C@@H:10]1[O:17]C(=O)[C@H](C)[O:13][C:11]1=[O:12].CCCCC(C([O-])=O)CC.CCCCC(C([O-])=O)CC.[Sn+2].C(O)CCCCCCCCCCC>C1(C)C=CC=CC=1>[C:2]([OH:4])(=[O:3])[CH2:1][OH:8].[C:11]([OH:13])(=[O:12])[CH:10]([CH3:9])[OH:17]

Komponenten

Reaktionsbedingungen

Temperatur: 220 °C

Versuchsvorschrift

1161 g (10 mols) of glycolide and 1441 g (10 mols) of L-lactide were placed in a glass reactor, and 10 ml of a toluene solution containing 0.26 g of stannous octoate and 9.0 g of lauryl alcohol were added to the reactor. Afterward, deaeration was carried out for 2 hours under reduced pressure, and the atmosphere in the reactor was then replaced with a nitrogen gas. This mixture was heated at 220° C. for 2 hours with stirring under the nitrogen atmosphere. While the temperature was maintained as it was, the deaeration was slowly performed by means of a vacuum pump through an exhaust pipe to reduce the pressure in the reactor to 3 mm Hg. One hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor was replaced with nitrogen and a resultant glycolic acid-lactic acid copolymer (hereinafter referred to as "PLGA") was then taken out.

Aufarbeitung

additionwere added to the reactor
temperatureWhile the temperature was maintained as it
extractionOne hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor

Quellen und Nachweise

ORD-Eintrag: ord-1521c8617741434ebf5cc202e22761c1
Quelldatensatz: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US05272221

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