Isopropylamine → 1-(Iso-propyl)-3-benzyloxyazetidine

HRID 328901Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 328901
[CH2:1]([O:8][CH:9]([CH2:12]Cl)[CH2:10]Cl)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:14]([NH2:17])([CH3:16])[CH3:15]>O>[CH2:1]([O:8][CH:9]1[CH2:12][N:17]([CH:14]([CH3:16])[CH3:15])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6363IsopropylamineHCID 5155009Benzene, [[2-chloro-1-(chloromethyl)ethoxy]methyl]-

Produkt 1

HCID 205173241-(Iso-propyl)-3-benzyloxyazetidineAusbeute 85 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

21.9 parts of 2-benzyloxy-1,3-dichloro-propane, 59.1 parts of iso-propylamine and 59.1 parts of water were added to an autoclave, and the mixture was heated at 90° C. for 48 hours with agitation. The reaction mixture was cooled and treated in the same manner as in Example 29, followed by distillation under reduced pressure. As a result 17.4 parts of 3-benzyloxy-1-(iso-propyl)azetidine boiling at 105° - 107° C. under 2 mm Hg were obtained. The yield was 85%. The results of infra-red spectrum analysis and nuclear magnetic resonance analysis of the product are as follows:

Aufarbeitung

  1. temperatureThe reaction mixture was cooled
  2. additiontreated in the same manner as in Example 29
  3. distillationfollowed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-233f80317ee848c4b4dba8f7305a6f7a
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018824

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