Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide

HRID 330782

Reaktionsgleichung

Reaktionsgleichung von HRID 330782
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][C:10]=1[OH:16]>C(O)(=O)C>[Cl:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:5](=[O:7])[CH3:6])=[CH:11][C:10]=1[OH:16]

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 806765-Amino-2-chlorophenol

Produkt 1

HCID 14122483N-(4-Chloro-3-hydroxyphenyl)acetamideAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

Aufarbeitung

  1. temperaturethe reaction was refluxed for 5 mins
  2. filtrationIt was filtered off
  3. washwashed with water (10 mL)
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-b36c980b138d4933833e7cd7a8fdd153
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877752B2

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