Sodium Hydroxide → (E)-N-[(3-Fluorophenyl)methylidene]hydroxylamine

To a suspension of 3-fluorobenzaldehyde (6.75 g, 54 mmol) and hydroxylamine hydrochloride (4.16 g, 60 mmol) in ethanol (4.3 mL) and water (13 mL) was added ice (25 g). Then a solution of sodium hydroxide (5.5 g, 138 mmol) in water (6.5 mL) was added dropwise within a 10 min period (temperature rises from −8° C. to +7° C.) whereupon most of the solid dissolves. After 30 min stirring at room temperature a white solid precipitated and the resulting mixture was then diluted with water and acidified with HCl (4 N). The white precipitate was then filtered off, washed with water and dried under high vacuum to afford the title compound (7.0 g, 93%) which was obtained as a white solid. MS m/e (EI): 139.1 [M].

1. dissolutiondissolves
2. customprecipitated
3. additionthe resulting mixture was then diluted with water
4. filtrationThe white precipitate was then filtered off
5. washwashed with water
6. customdried under high vacuum

ORD-Eintrag

ord-7109c2edc16d4e738d3043262b358010

Quelldatensatz

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08877783B2