Water → HCID 66987744, Verbindung

HRID 333421

Reaktionsgleichung

Reaktionsgleichung von HRID 333421
[CH:1]1([NH:4][CH:5]2[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:7][CH2:6]2)[CH2:3][CH2:2]1.C(N(CC)CC)C.[C:25](Cl)(=O)[CH2:26][CH3:27].[OH2:30]>C1COCC1>[CH:26]1([CH2:2][CH2:3][C:1]([NH:4][CH:5]2[CH2:6][CH2:7][N:8]([C:11]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:12])[CH2:9][CH2:10]2)=[O:30])[CH2:27][CH2:25]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 62324Propionyl chlorideHCID 2769591tert-Butyl 4-(cyclopropylamino)piperidine-1-carboxylate

Produkt 1

HCID 66987744HCID 66987744, VerbindungAusbeute 89 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.8 g (3.3 mmol) of tert-butyl 4-cyclopropylaminopiperidine-1-carboxylate, 0.48 mL (3.3 mmol) of triethylamine and 0.56 mL (3.3 mmol) of propionyl chloride are dissolved in 50 mL of THF. The reaction medium is stirred for 2 hours at room temperature. The reaction is stopped by adding water and the organic products are then extracted with dichloromethane. The organic phase is dried and then evaporated. The crude product obtained is chromatographed on silica gel (eluent: 6/4 heptane/ethyl acetate). 0.87 g of tert-butyl 4-(cyclopropylpropionylamino)piperidine-1-carboxylate in the form of a colourless oil is obtained in a yield of 89%.

Aufarbeitung

  1. extractionthe organic products are then extracted with dichloromethane
  2. customThe organic phase is dried
  3. customevaporated
  4. customThe crude product obtained
  5. customis chromatographed on silica gel (eluent: 6/4 heptane/ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-1de102abcc1d483ab3fa12abd58096c9
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877968B2

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