Water → N-[3-Benzyl-5-(4-methoxyphenyl)pyrazin-2-yl]-6-methoxy-N-(6-methoxy-1-naphthoyl)-1-naphthamide

HRID 333632

Reaktionsgleichung

Reaktionsgleichung von HRID 333632
[CH2:1]([C:8]1[C:9]([NH2:22])=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:23][O:24][C:25]1[CH:26]=[C:27]2[C:32](=[CH:33][CH:34]=1)[C:31]([C:35](Cl)=[O:36])=[CH:30][CH:29]=[CH:28]2.[OH2:38]>N1C=CC=CC=1.CN(C)C1C=CN=CC=1>[CH2:1]([C:8]1[C:9]([N:22]([C:35]([C:31]2[C:32]3[C:27](=[CH:26][C:25]([O:24][CH3:23])=[CH:34][CH:33]=3)[CH:28]=[CH:29][CH:30]=2)=[O:38])[C:35]([C:31]2[C:32]3[C:27](=[CH:26][C:25]([O:24][CH3:23])=[CH:34][CH:33]=3)[CH:28]=[CH:29][CH:30]=2)=[O:36])=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

6

Edukt 3

HCID 962WaterHCID 113007862-Amino-3-benzyl-5-(4-methoxyphenyl)pyrazineHCID 575166936-Methoxy-1-naphthoyl chloride

Produkt 1

HCID 67432726N-[3-Benzyl-5-(4-methoxyphenyl)pyrazin-2-yl]-6-methoxy-N-(6-methoxy-1-naphthoyl)-1-naphthamideAusbeute 68,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 142844-(Dimethylamino)pyridineKatalysatorHCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Under an argon atmosphere, to a solution of 3-benzyl-5-(4-methoxyphenyl)pyrazin-2-amine (12) (synthesized by the process of M. Adamczyk, et al., Org. Prep. Proced. Int., 33, 477-485 (2001)) (500 mg, 1.72 mmol) in pyridine (5 mL) were successively added 4-(dimethylamino)pyridine (21.0 mg, 172 μmol) and 6-methoxy-1-naphthoyl chloride (22) prepared above at room temperature, and the mixture was heated with stirring at 50° C. 18 hours. After cooling to room temperature, to the mixture was added water and the product was extracted with dichloromethane (×3). The combined organic extract was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residual pyridine was azeotropically removed with toluene (×3). The residue was successively purified twice by column chromatography (silica gel 50 g, dichloromethane/ethyl acetate=9/1, and silica gel 50 g, n-hexane/ethyl acetate=2/1) to give Compound 11z (775 mg, 1.17 mmol, <68.3%) as a brown foamy solid containing some impurities. Rf=0.21 (n-hexane/ethyl acetate=2/1); 1H NMR (400 MHz, DMSO-d6) δ 3.82 (s, 3H), 3.83 (s, 6H), 4.39 (s, 2H), 7.04-7.09 (AA′BB′, 2H), 7.15-7.23 (m, 6H), 7.26-7.31 (m, 1H), 7.34-7.41 (m, 4H), 7.63-7.69 (m, 2H), 7.75-7.80 (AA′BB′, 2H), 8.02-8.08 (m, 4H), 9.07 (s, 1H).

Aufarbeitung

  1. customprepared above at room temperature
  2. temperaturethe mixture was heated
  3. custom18 hours
  4. temperatureAfter cooling to room temperature, to the mixture
  5. extractionthe product was extracted with dichloromethane (×3)
  6. extractionThe combined organic extract
  7. dry with materialwas dried over anhydrous sodium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated under reduced pressure
  10. customThe residual pyridine was azeotropically removed with toluene (×3)
  11. customThe residue was successively purified twice by column chromatography (silica gel 50 g, dichloromethane/ethyl acetate=9/1, and silica gel 50 g, n-hexane/ethyl acetate=2/1)

Quellen und Nachweise

ORD-Eintrag
ord-8afc8beb1f7840b8aba6c03887d2ef67
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883432B2

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