Bromine → 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione

HRID 334151

Reaktionsgleichung

Reaktionsgleichung von HRID 334151
[NH:1]1[C:6]2[CH:7]=[CH:8][S:9][C:5]=2[C:4](=[O:10])[NH:3][C:2]1=[O:11].[Br:12]Br>C(O)(=O)C>[Br:12][C:7]1[C:6]2[NH:1][C:2](=[O:11])[NH:3][C:4](=[O:10])[C:5]=2[S:9][CH:8]=1

Komponenten

4

Edukt 2

HCID 24408BromineHCID 7059273Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 183264277-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dioneAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (10.38 g, 61.72 mmol) was dissolved in acetic acid (230 mL) and Bromine (11.13 mL, 216 mmol) was added. The reaction was heated at 80° C. for 3.5 h. Complete reaction was confirmed by LCMS. The reaction mixture was poured onto ice water slowly and filtered off the precipitate which was dried overnight under vacuum to give 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9.1 g, 60% yield)

Aufarbeitung

  1. customComplete reaction
  2. additionThe reaction mixture was poured onto ice water slowly
  3. filtrationfiltered off the precipitate which
  4. customwas dried overnight under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-2b62709c92634f6d93054bc037e3db69
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883799B2

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