1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 335049

Reaktionsgleichung

Reaktionsgleichung von HRID 335049
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(O)(=O)C>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

Komponenten

4

Edukt 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

Produkt 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a solution of 1-hydroxy-2-naphthoic acid (10.2 g, 53.9 mmol) in 100 mL of acetic acid was added bromine (6.60 mL, 53.9 mmol) dropwise. After 72 hours, the reaction was filtered and the filter cake was washed with acetic acid (40 mL) and hexanes (150 mL) to provide 4-bromo-1-hydroxy-2-naphthoic acid that gave a proton NMR spectra consistent with theory.

Aufarbeitung

  1. filtrationthe reaction was filtered
  2. washthe filter cake was washed with acetic acid (40 mL) and hexanes (150 mL)

Quellen und Nachweise

ORD-Eintrag
ord-da2eefd0dd944cde9cff264726e045a2
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883850B2

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