Potassium Carbonate → HCID 86658462, Verbindung

HRID 335857Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 335857
C([O-])(=O)C.[K+].FC(F)(F)S(O[C:12]1[CH:13]=[C:14]2[C@@:25]3([CH2:29][O:28][C:27]([NH2:30])=[N:26]3)[C:24]3[C:19](=[N:20][CH:21]=[C:22](C#CC4(C)COC4)[CH:23]=3)[O:18][C:15]2=[CH:16][CH:17]=1)(=O)=O.B1(B2OC(C)(C)C(C)(C)O2)OC(C)(C)C(C)(C)O1.BrC1C=NC=CC=1F.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.CCOC(C)=O.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.O>[O:28]1[CH2:29][C:25]2([C:24]3[C:19](=[N:20][CH:21]=[CH:22][CH:23]=3)[O:18][C:15]3[C:14]2=[CH:13][CH:12]=[CH:17][CH:16]=3)[N:26]=[C:27]1[NH2:30]

Komponenten

11

Edukt 5

HCID 11430Potassium CarbonateHCID 517044Potassium AcetateHCID 2733548Bis(pinacolato)diboraneHCID 27627793-bromo-4-fluoropyridineHCID 86640736HCID 86640736, Verbindung

Produkt 1

HCID 86658462HCID 86658462, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 5

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 178418807HCID 178418807, VerbindungKatalysatorHCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A solution of potassium acetate (0.210 g, 2.140 mmol), PdCl2(dppf)-CH2Cl2 adduct (0.022 g, 0.027 mmol), (S)-2′-amino-3-((3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazole]-7-yl trifluoromethanesulfonate (0.265 g, 0.535 mmol), and bis(pinacolato)diboron (0.143 g, 0.562 mmol) in 5 mL DMF was heated to 100° C. for 3 hours. Pd(PPh3)4 (0.031 g, 0.027 mmol) was added, followed by 3-bromo-4-fluoropyridine (0.141 g, 0.802 mmol), potassium carbonate (0.296 g, 2.140 mmol), and 2 mL water. The reaction mixture was capped with argon and was heated to 100° C. for 2 hours. After cooling to RT, the reaction mixture was diluted with EtOAc and was washed sequentially with water and brine. The organics were dried over MgSO4 and concentrated. Purification of the crude residue by column chromatography [0-100% (9:1 CH2Cl2:MeOH)/CH2Cl2] then HPLC (10-90% MeCN/H2O) provided (S)-7-(4-fluoropyridin-3-yl)-3-(3-methyloxetan-3-yl)ethynyl)-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine. MS m/z=443.0 [M+H].

Aufarbeitung

  1. customThe reaction mixture was capped with argon
  2. temperatureAfter cooling to RT
  3. washwas washed sequentially with water and brine
  4. dry with materialThe organics were dried over MgSO4
  5. concentrationconcentrated
  6. customPurification of the crude residue by column chromatography [0-100% (9:1 CH2Cl2:MeOH)/CH2Cl2]

Quellen und Nachweise

ORD-Eintrag
ord-2d7ceb8ab0ef4e0ca032bd1c40acdecd
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883782B2

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