Diethyl Ether → N-(4,6-dimethyl-1-octyl-5-sulfamoylaminoindolin-7-yl)-2,2-dimethylpropanamide hydrochloride

HRID 33600Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 33600
C(OC([NH:8][S:9]([NH:12][C:13]1[C:14]([CH3:38])=[C:15]2[C:19](=[C:20]([NH:23][C:24](=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]=1[CH3:22])[N:18]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:17][CH2:16]2)(=[O:11])=[O:10])=O)(C)(C)C.[ClH:39].CC(O)C.C(OCC)C>C(O)=O>[ClH:39].[CH3:38][C:14]1[C:13]([NH:12][S:9](=[O:10])(=[O:11])[NH2:8])=[C:21]([CH3:22])[C:20]([NH:23][C:24](=[O:29])[C:25]([CH3:26])([CH3:27])[CH3:28])=[C:19]2[C:15]=1[CH2:16][CH2:17][N:18]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

Komponenten

5

Edukt 3

HCID 3283Diethyl EtherHCID 21912024Isopropanol hydrochlorideHCID 23075439N-[5-(N-tert-butoxycarbonylsulfamoylamino)-4,6-dimethyl-1-octylindolin-7-yl]-2,2-dimethylpropanamide

Produkt 1

HCID 23075405N-(4,6-dimethyl-1-octyl-5-sulfamoylaminoindolin-7-yl)-2,2-dimethylpropanamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

The compound (1.86 g) obtained in Example 5 was dissolved in formic acid (7.5 mL) and 8.51 M hydrogen chloride—2-propanol solution (1.98 mL) was added under ice-cooling. The mixture was stirred at the same temperature for 20 min. Diethyl ether (50 mL) was added, and the precipitated crystals were collected by filtration to give the title compound as crystals (1.34 g).

Aufarbeitung

  1. temperaturecooling
  2. filtrationthe precipitated crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-ec3ce743e04749299e8162d16b63a862
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429612B2

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