Methane → 2-(Methoxymethyl)aniline

HRID 339005

Reaktionsgleichung

Reaktionsgleichung von HRID 339005
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N+:10]([O-])=O.[H][H].C>CO.O=[Pt]=O>[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH2:10]

Komponenten

6

Edukt 3

HCID 297MethaneHCID 126166891-(Methoxymethyl)-2-nitrobenzeneHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 123343062-(Methoxymethyl)anilineAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 345198Adams' catalystKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-(methoxymethyl)-2-nitrobenzene (4.30 g, 25.7 mmol) and PtO2 (0.29 g, 1.29 mmol) in MeOH (30 mL) was charged with 1 atmosphere hydrogen and stirred at ambient temperature for 1 hour. Charcoal (5 g) was added and the reaction mixture was stirred for 10 minutes. The solid was removed by filtration and washed with methanol. The filtrate was concentrated under reduced pressure to give 2-(methoxymethyl)aniline (3.42 g, 96.9%) as a solid.

Aufarbeitung

  1. stirringthe reaction mixture was stirred for 10 minutes
  2. customThe solid was removed by filtration
  3. washwashed with methanol
  4. concentrationThe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f7367e47b3244552ae1321ad6a778546
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889704B2

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